*The table reflects doses of benzodiazepines that are approximately equivalent to 5 mg of diazepam
Converting a patient from 1 mg alprazolam to Rivotril®:
0.5 mg alprazolam = ~0.25 mg Rivotril®
1 mg per day administered at bedtime after 3 days of initial treatment 1
Initially: 0.25 mg twice daily (0.5 mg/day). The dose may be increased to the target dose of 1 mg/ day after 3 days 1
Some individual patients may benefit from doses of up to a maximum dose of 4 mg/day, and in those instances the dose may be increased in increments of 0.125 to 0.25 mg twice a day, every 3 days until panic disorder is controlled or until side-effects make further increases undesired 1
To reduce the inconvenience of somnolence, administration of one dose at bedtime may be desirable 1
Treatment should be discontinued gradually, with a decrease of 0.125 mg twice a day every 3 days, until the medicine is completely withdrawn 1
1.5 mg/day divided into three doses
3 - 6 mg/day
Incremental increases of 0.5 mg every third day until either seizures are adequately controlled, or undesired effects preclude any further increase
Increase the daily dose progressively to avoid initial side-effects.
Use the drop formulation (1 drop = 0.1 mg) in infants and children to obtain optimum adjustment of the dosage.
Mix the drops with water, tea or fruit juice and administer with a spoon. Do not administer Rivotril® drops directly into the mouth from the bottle.
Use the 0.5 mg tablet formulation in children and adults to facilitate the administration of lower daily doses in the initial stages of treatment.
In adults, the daily dose should be divided into three equal doses. If the doses are not equally divided, the largest dose should be given before going to sleep. Once the maintenance dose has been reached in adults, the daily amount may be given as a single dose in the evening.
Treatment should be discontinued gradually. Reduce the dosage in a stepwise manner.